NAD+ Injections in Canada: Cost, Access and What the Evidence Says

What NAD+ is

Nicotinamide adenine dinucleotide is a coenzyme present in every cell, central to converting nutrients into cellular energy and to the activity of enzymes involved in DNA repair. Tissue NAD+ levels decline with age. That observation is well established and is the entire premise behind NAD+ therapy: restore the coenzyme, support the processes that depend on it.

Where the evidence actually stands

It is worth being straight about this. The decline of NAD+ with age is well documented, and preclinical work on restoration is genuinely interesting. Human clinical evidence that supplementation produces meaningful functional or longevity benefits is still early, and much of what circulates online overstates it. NAD+ therapy is reasonable to explore with clinician supervision; it is not an established treatment with guaranteed outcomes, and anyone telling you otherwise is selling something.

Injection versus infusion in Canada

Two delivery routes are available here. In-clinic intravenous infusions typically run $600 or more per session and require you to sit in a clinic for one to several hours. At-home subcutaneous injections, prescribed by a licensed Canadian clinician and dispensed by a licensed pharmacy, run around $299 per month with oversight, dosing and delivery included.

For most people the at-home route is the practical one, on cost and on logistics. The trade-off is that it requires comfort with self-injection.

It is prescription-only

Injectable NAD+ must be prescribed by a clinician licensed in your province and dispensed by a licensed Canadian pharmacy. A platform that ships injectable NAD+ to a Canadian address without a clinical assessment is not operating within Canadian regulation. Expect a health history review before your first shipment, and expect a legitimate provider to decline if treatment is not appropriate for you.

Who tends to consider it

The common motivations are energy, recovery, mental clarity and general healthy-aging interest. None of those are diagnoses, which is part of why the evidence base is hard to build — the endpoints are subjective. If you have a specific treatable cause of fatigue (anaemia, thyroid disease, sleep apnoea, depression), rule that out first. NAD+ therapy is not a substitute for diagnosing something real.

What to check before starting

1. Is the prescribing clinician licensed in your province?
2. Is the dispensing pharmacy Canadian-licensed, and is the platform LegitScript certified?
3. Is the monthly price genuinely all-in, or does clinician oversight cost extra?
4. Is there a cancellation path that does not require a phone call you cannot get through?